CrownCast
In the last two decades, oncology has undergone a transformation with over 300 new cancer therapies approved by the FDA—many offering novel mechanisms of action. Despite these innovations, resistance to treatment remains a critical challenge, with cancer cells evolving or adapting to evade even the most advanced therapeutics. This issue is particularly pressing given that…
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Crown BioScience
Growing the Future of Cancer Research: Inside the Promise of Organoids
In an era where precision and predictability define the future of oncology, organoid technology is emerging as a transformative tool in drug discovery. These miniature, lab-grown 3D tissues mirror real human biology more closely than traditional 2D models or even animal systems, offering researchers the potential to predict patient-specific drug responses. As organoids become more…
Crown BioScience
Shaping the Future of Cancer Care Through Immuno-Oncology
In the ever-evolving world of cancer treatment, immuno-oncology (IO) continues to stand at the forefront of innovation. With recent FDA approvals for TIL therapies and bispecific antibodies, and new developments in CAR-T technologies, the field is rapidly expanding into combination-based strategies that integrate with standard care. Researchers are also exploring how to overcome challenges posed…
Crown BioScience
Evolving Biomarkers: Charting the Future of Precision Medicine
In a rapidly shifting landscape of personalized medicine, biomarkers have become central to shaping the way drug development and clinical trials unfold. From predicting therapeutic response to identifying optimal patient populations, the complexity and scope of biomarker use has increased alongside technological advances. A key success story like the BCR-ABL biomarker in chronic myeloid leukemia…
Crown BioScience
Exploring Artificial Intelligence in Drug Discovery
Artificial intelligence is rapidly reshaping the drug discovery process, moving from augmenting research to actively driving innovation. As biotech companies face soaring R&D costs and long development cycles, AI promises a breakthrough: slashing drug development time by nearly half while improving accuracy in identifying promising compounds. With global pharmaceutical R&D spending projected to exceed $230…
Crown BioScience
Pioneering Strategies to Unlocking the Potential of KRAS
Once labeled “undruggable,” KRAS has emerged as one of oncology’s most promising—yet complex—targets. With nearly 90% of pancreatic cancers and 30-40% of lung and colorectal cancers harboring KRAS mutations, the need for effective therapies is urgent. Recent FDA approvals of KRAS G12C inhibitors have signaled a new era, but the rise of resistance and diverse…
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Scaling Experiential Learning in the Curriculum: How Iron Range Engineering Transformed Engineering Education
Engineering has transformed nearly every part of modern life, from the phones in our pockets to the systems powering global industry. But the way engineers are educated has often moved far more slowly than the profession itself. Employers are asking for graduates who can navigate ambiguity, communicate across teams, and contribute meaningfully from the…
When Geography Meets Purpose: How One Move Reshaped a Vascular Surgeon’s Career
Medicine isn’t what it used to be—not for the people practicing it. Independent physicians are becoming the exception, not the norm, as more doctors move into hospital systems, corporate groups, and academic networks. At the same time, the pipeline of specialists isn’t keeping pace with growing patient needs, particularly in complex fields like vascular…
From Second Chances to Stronger Teams: Bradley Henderson on Structure, Culture, and Trades-Based Redemption
The trades have always demanded grit, but grit alone doesn’t build a strong workforce. People need structure, clear expectations, and a sense that their work is taking them somewhere. That’s especially true in HVAC and mechanical services, where employers are trying to hire, retain, and develop talent in a labor market that feels tighter and…
Creative Confidence and Moral Courage: The Leadership Traits Business Schools Should Be Betting On
What students need from higher education is becoming harder to pin down than it once was. As higher education faces mounting pressure—from student disengagement to the rapid rise of artificial intelligence—institutions are being forced to rethink not just what students learn, but who they become. New research and industry signals suggest that technical knowledge…
