Chaperones Aren’t Just for the Prom: Key Step In Viral Replication Identified

Viruses are cellular parasites that reproduce themselves by hijacking the machinery of the cells they infect. We have significant knowledge regarding cell infection and virus reproduction of themselves within cells, but scarce is our understanding of the final stages of protein folding and virus construction. However, according to SciTechDaily, researchers at Children’s Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine have published a report in Nature Microbiology revealing how the proteins of the common, normally harmless reovirus, are properly folded by the cell to produce the final viruses. 

The key is the common chaperonin protein complex, TriC. A given protein can potentially fold multiple ways, but the chaperonins help proteins in the cell to fold properly. In fact, it helps fold up to 10% of all the cell’s proteins, including important proteins such as cellular cytoskeleton proteins and cell cycle regulators. TriC is highly conserved across species, indicating its importance in proper protein folding and function. This conserved structure also suggests that TriC might be a common protein for viruses to use. 

The TriC helps the reovirus’s outer capsid proteins to fold such that they can assemble into virus particles capable of being released from the cell to infect new cells. Given the central role of TriC in properly folding reovirus proteins, scientists may find ways to inhibit the folding process. However, given the central importance of TriC as a chaperonin for 10% of the cell’s proteins, therapies must be conducted carefully to avoid damage to the cells themselves. 

Whether new therapies can be developed or not, understanding the roles of chaperonins like TriC is an important step to understanding the virus lifecycle. The more we understand about how viruses take over the cellular structure, the closer we are to understanding how to therapeutically fight these miniscule cellular parasites.

Follow us on social media for the latest updates in B2B!

Image

Latest

innovations in healthcare
Innovations in Healthcare: A Discussion with Dr. Craig Joseph at HIMSS 2024
May 24, 2024

Innovations in healthcare were easy to spot at the recent HIMSS 2024 conference. Healthcare Rethink’s Brian Urban caught up with one of those innovators for a live discussion at HIMSS 2024. podcast, Their conversation opens a window and dialogue into the cutting-edge trends reshaping healthcare technology today. This episode features Dr. Craig Joseph, the…

Read More
Preventing burnout
Achieving Professional Growth and Preventing Burnout: The Importance of Time Management and Support Networks in a Fast-Paced World
May 23, 2024

In today’s fast-paced world, balancing professional growth with personal well-being is more crucial than ever. With the rise of remote work, digital transformation, and the constant hustle culture, finding this balance has become a significant challenge for many. A survey conducted by Deloitte suggests that a whopping 77% of professionals experience burnout at work….

Read More
Fan-Centric Business Transformation
Prop Room
May 23, 2024

In this episode of the Fans First series, Jesse Cole, the mastermind behind the Savannah Bananas, shares with us that in the vibrant world of marketing, creativity knows no bounds—a philosophy embodied by a prop room and studio teeming with eclectic costumes and outlandish ideas. This creative hub, seemingly disconnected from conventional themes like bananas,…

Read More
Ace Gardner and Jacob Lewis discuss NIL Deals and Transfer Portals
NIL Deals and Transfer Portals are Also Impacting College Staff and Their Roles
May 23, 2024

College sports is undergoing a significant transformation with the advent of Name, Image, and Likeness (NIL) rights and the increasing prevalence of transfer portals. These changes are reshaping how college staff operate, presenting both opportunities and challenges. With the rise of NIL deals and transfer portals, understanding the behind-the-scenes impact on college coaching staff…

Read More