New Study: Probiotic DE111® Shown to Promote a Healthy Microbiome for Immune Support in Daycare-Attending Children

KENNESAW, GA (December 2, 2020) – Deerland Probiotics and Enzymes has announced the publication of a clinical study showing that the administration of the probiotic Bacillus subtilis DE111® can modify the composition of the microbiome in preschool-aged children.

The study, “Daily intake of probiotic strain Bacillus subtilis DE111 supports a healthy microbiome in children attending day-care” published in Beneficial Microbes, is an IRB-approved, randomized, double-blind, placebo-controlled four-week trial involving 91 children aged 2 to 6. Results of the study showed that daily consumption of the probiotic strain Bacillus subtilis DE111 positively modulated the gut microbiome profile without changing the overall microbiome equilibrium.

After 8 weeks of daily probiotic consumption, the researchers observed an increase in alpha-diversity at the phylum level, suggesting an expanded functional diversity of the microbiome compared to that of the children in the placebo group. Specifically, there were 9 differentially abundant taxa at the genus level found in the probiotic group, six (of the phylum bacteroidetes) grew in abundance while three (of the phylum firmicutes) were reduced. The six taxa of bacteroidetes that flourished are involved in immune regulation and reduction of inflammation. This modulation of the firmicutes/bacteroidetes ratio of the microbiome in children taking B. subtilis DE111 is a positive indication for healthy gut function.

Overall, according to the researchers, these results suggest B. subtilis DE111 supports the maintenance of a healthy gut through subtle modulations of the microbiome with significant benefits in preschool aged children.

“On the dawn of a new highly modified school year where health takes center stage, this study is highly encouraging to formulate natural, safe products for young children to promote immunity and overall well-being so they can concentrate on learning,” said John Deaton, vice president of science and technology at Deerland. “Focusing on supporting a healthy microbiome will result in more robust and effective immunity as children get older.”

Deerland Probiotics & Enzymes, based in Kennesaw, Ga., specializes in developing science-backed solutions that benefit microbiome health, using probiotic, prebiotic and enzyme technology.  The company offers a line of unique, clinically validated branded products, including DE111®, PreforPro®, ProHydrolase®, Solarplast®, Glutalytic® and Bifolac® probiotic strains.  Deerland collaborates with customers to develop innovative and often proprietary solutions in the dietary supplement, food and beverage, sports nutrition, and companion animal markets. In addition to branded ingredients and customized formulations, Deerland offers full turnkey products for private label through its YourBrand® portfolio.  The company’s manufacturing services include bulk blends, capsules, stick packs and tablets, as well as bottling and labeling. To contact Deerland Probiotics & Enzymes, call 800.697.8179 or visit www.deerland.com.

Follow us on social media for the latest updates in B2B!

Image

Latest

symmetry CONNECT
Introducing Symmetry Connect: Automating Physical Identity and Access Management
April 2, 2025

In today’s fast-paced, security-conscious environment, managing who has access to what—and when—is more critical than ever. That’s where Symmetry CONNECT Identity Management by AMAG comes in, offering a powerful, streamlined solution for physical identity and access management (PIAM). With growing compliance demands and increasingly complex workforces, organizations need tools that can automate onboarding, simplify credentialing,…

Read More
data center construction
Data Center Construction Demands Are Surging But Power, Permitting, and Planning Are Holding It Back
April 1, 2025

Explosive demand for artificial intelligence, cloud services, and low-latency connectivity is reshaping the landscape for data center construction in the U.S. With hyperscalers and enterprises alike racing to deploy infrastructure closer to end users, new builds are increasingly challenged by the need for high-capacity power, complex permitting, and skilled labor. According to CBRE, U.S….

Read More
intelligent audio systems
Redefining Security: The Critical Role of Voice in Intelligent Audio Systems
April 1, 2025

In the world of security technology, vision has long taken precedence—cameras, analytics, and access control have dominated the conversation. But what if we’ve been underestimating our oldest, most human sense of communication: voice? The rise of intelligent audio in security systems marks a turning point in how we protect spaces and people, shifting from passive…

Read More
How PSA is Empowering Integrators to Navigate AI, Mobile Credentials, and Modern Business Challenges?
April 1, 2025

As the security integration industry contends with rapid technological advancement and increasing business complexity, many integrators are looking for the tools, training, and guidance to keep pace. At the center of this evolution is AI—transforming not just the products integrators deploy but also the way they operate their businesses. Meanwhile, the shift to mobile credentials…

Read More