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BioTech Startups Want to Revive Failed Medicines to Create New Lifesaving Treatments

Some Cancer-fighting compounds for kids gather dust on Big Pharma’s lab shelves. Children’s Tumor Foundation President Annette Bakker, Ph.D., won’t stand for that. She shared her efforts to rescue these assets with I Don’t Care’s Kevin Stevenson. In her fight to end neurofibromatosis, an incurable condition that causes tumors to grow on the brain and…

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Some Cancer-fighting compounds for kids gather dust on Big Pharma’s lab shelves. Children’s Tumor Foundation President Annette Bakker, Ph.D., won’t stand for that. She shared her efforts to rescue these assets with I Don’t Care’s Kevin Stevenson.

In her fight to end neurofibromatosis, an incurable condition that causes tumors to grow on the brain and spinal cord, Bakker is pioneering game-changing ideas in disease research.

Through Bakker’s experience in the pharmaceutical and biochemistry industries, she learned how separate the two ecosystems were. “The motivations that drive academic researchers are publications,” Bakker said. “The motivations that drive pharmaceutical companies is to develop those drugs, but in the meantime also to fuel the development of new drugs they need to patent. So, they need to keep the stuff secret. The very different systems these two worlds are living in make it difficult to translate discoveries into better treatments for patients.”

Bridging the gap in science politics to ensure discoveries lead to better treatments is the space where Bakker lives. “It’s about bringing the models to the drugs,” Bakker said. “It’s about bringing the different stakeholders together and creating that ecosystem.”

What led Bakker from her background in biochemistry to the pharmaceutical world was the desire to take great discoveries and make sure they were getting used. And what ultimately led her to The Children’s Tumor Foundation (CTF) was to be a part of the solution in bridging the gaps, cutting through the red tape, and connecting the right people to make real change. “My philosophy is always, ‘move the foot,’ Bakker said. “Don’t blame anyone; incentivize them to change their behavior and feel good about it.”

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Smart ICU and ambient AI cut errors when they feed data and notes into the EMR

Smart ICU and ambient AI cut errors when they feed data and notes into the EMR

Two HIMSS26 APAC case studies point to the same operational lesson: hospitals are getting measurable gains from “smart ICU” device integration and ambient AI documentation only when those tools are tightly integrated into core clinical workflows. Pondok Indah Hospital Group in Indonesia reported reductions of up to 70% in ICU administrative errors and 40% in adverse drug reactions after integrating smart devices, according to Healthcare IT News. Sir H.N. Reliance Foundation Hospital in India reported ambient AI is now used for nearly 90% of progress notes and shift handovers across five live use cases on a single EMR-integrated platform, also reported by Healthcare IT News. New JAMA Network cardiovascular research adds a parallel signal on the clinical side, with AI-enabled acquisition and interpretation approaches moving into screening and triage workflows, which raises procurement questions about validation, interoperability, and change management at the bedside.

  • 01A useful benchmark is emerging for documentation automation: “nearly 90% of progress notes and shift handovers” on ambient AI when it is deployed as one EMR-integrated platform, not a set of point tools (Healthcare IT News).
  • 02The measurable ROI in ‘smart ICU’ programs shows up where operators feel pain: fewer administrative errors and medication-related events, not in abstract “digitization” metrics (Healthcare IT News reported up to 70% and 40% reductions, respectively).
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  • 01A useful benchmark for planning: Gartner pegs AI spend growth in customer service at 38% versus 2% budget growth overall, a mismatch that forces reallocation and harder ROI proof.
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  • 02AI-delivered patient education must meet three criteria: solve a meaningful clinical or financial problem, integrate naturally into care workflows, and avoid adding burden to patients or clinicians
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